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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1988-10-18
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pubmed:abstractText |
Treatment of Halobacterium GRB cells with the DNA topoisomerase II inhibitor novobiocin induces the accumulation of a circular single-stranded DNA form of the plasmid pGRB-1. This form corresponds to the transcribed strand of pGRB-1. A tiny amount of this form is detectable in untreated cells. The induction of single-stranded pGRB-1 molecules by novobiocin is abolished when cells are pretreated with aphidicolin or anisomycin, which inhibit halobacterial DNA replication and protein synthesis, respectively. These results suggest that the single-stranded form of pGRB-1 is generated in the course of plasmid replication.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-2828337,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-3085097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-3121311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-3123220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-3347494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-3671082,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-368801,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-3714493,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-4931423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-6097803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-6159641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-6204969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-73185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3419901-791945
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7833-42
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3419901-Bacterial Proteins,
pubmed-meshheading:3419901-DNA, Circular,
pubmed-meshheading:3419901-DNA, Single-Stranded,
pubmed-meshheading:3419901-DNA Replication,
pubmed-meshheading:3419901-Halobacterium,
pubmed-meshheading:3419901-Novobiocin,
pubmed-meshheading:3419901-Plasmids,
pubmed-meshheading:3419901-Transcription, Genetic
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pubmed:year |
1988
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pubmed:articleTitle |
Novobiocin induces accumulation of a single strand of plasmid pGRB-1 in the archaebacterium Halobacterium GRB.
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pubmed:affiliation |
Laboratoire de Biologie Moléculaire de la Replication, CNRS-IRSC, Villejuif, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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