Linked Life Data

3418014

Source:http://linkedlifedata.com/resource/pubmed/id/3418014

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-10-17
pubmed:abstractText
Electrophysiological and neuroanatomical studies indicate that reciprocal connections between the paraventricular nucleus (PVH) and medullary sites are involved in cardiovascular regulation. To determine whether the PVH is involved in the regulation of baroreflex responses, lumbar sympathetic nerve activity (LSNA) and heart rate (HR) changes were recorded in response to increases in arterial pressure (produced by bolus doses of phenylephrine i.v.) prior to, during, and 60 min following the injection of lidocaine (2% lidocaine, 200 nl) bilaterally in the PVH of chloralose-anesthetized rabbits. Baseline blood pressure, HR, and LSNA did not change in response to the administration of lidocaine in the PVH. The magnitude of 'baroreflex responses' in HR and LSNA were expressed as the ratios of maximal changes in these parameters divided by the corresponding maximal changes in blood pressure. Application of lidocaine to the PVH produced a significantly greater decrease in LSNA (greater than 50%) compared to prelidocaine responses to baroreceptor stimulation. This increase in baroreflex response returned to the normal level during the recovery phase. In contrast, there was no significant change in the response of the HR to baroreceptor stimulation. Administration of norepinephrine into the PVH, intended to simulate possible changes in noradrenergic function, did not affect either LSNA or HR responses to baroreceptor stimulation. Interruption of neural activity in the PVH, augmented the inhibitory response of LSNA but not HR to baroreceptor stimulation. These results indicate that changes in peripheral sympathetic nerve activity and HR in response to baroreceptor activation may be affected differentially by specific forebrain structures such as PVH.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0165-1838
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
211-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Role of paraventricular nucleus (PVH) in baroreflex-mediated changes in lumbar sympathetic nerve activity and heart rate.
pubmed:affiliation
Department of Physiology and Pharmacology, USD School of Medicine, University of South Dakota, Vermillion.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't