Linked Life Data

3417852

Source:http://linkedlifedata.com/resource/pubmed/id/3417852

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-10-24
pubmed:abstractText
The total number and saturation of nuclear receptors for T3 were measured in human fetal brain and lung from the 9th to the 13th week of fetal life. The concentrations of occupied and unoccupied receptor sites were determined by measuring total binding capacity at 0 and 22 C. At 0 C [125I]T3 was bound mainly to unoccupied sites, whereas at 22 C it was bound to unoccupied sites plus a fraction (70%) of endogenously occupied sites. Saturations of brain and lung receptors were similar (12-27%). From the fractional receptor occupancy and the receptor dissociation constants (34 pmol/L in brain and 56 pmol/L in lung) the concentration of intranuclear free T3 was calculated to be 9 pmol/L in brain and 11 pmol/L in lung. Total and free cytosolic T3 were measured by RIA and equilibrium dialysis. Total T3 was below the limit of detection in lung (90 pmol/L). The concentration of free T3 in brain cytosol was 0.95 pmol/L at 11 weeks and 2.96 pmol/L at 13 weeks, i.e. considerably lower than the nuclear free T3 concentration. These results suggest the presence of a small gradient (3-fold) between nuclear and cytosolic free T3 in both fetal tissues. The data strongly support the idea that thyroid hormones influence human brain development at least from the 9th to the 10th week of gestational age.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
853-6
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Estimation of nuclear thyroid hormone receptor saturation in human fetal brain and lung during early gestation.
pubmed:affiliation
Unidad de Endocrinologia, CSIC, Facultad de Medicina, UAM, Madrid, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't