Linked Life Data

3416917

Source:http://linkedlifedata.com/resource/pubmed/id/3416917

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-10-21
pubmed:abstractText
The effects of detomidine, a veterinary sedative analgesic, were studied in the horse. Novel objective techniques were employed to assess the analgesic and sedative potency of this compound. Intravenous doses of 0.010, 0.020 and 0.040 mg/kg were administered to eight adult Thoroughbred racehorses according to a double-blind crossover design. Analgesia was measured by determining the latency to onset of the skin twitch and hoof withdrawal reflexes following noxious thermal stimulation of the withers and fetlock, respectively. Sedation was assessed by quantifying spontaneous locomotor activity in horses confined to an activity chamber, and by electronic measurement of head ptosis. Linear, dose-related increases in the intensity and duration of analgesia were observed. However, dose-related increases in duration, rather than intensity of sedation were observed. In conclusion, detomidine is an effective analgesic in the horse, but it is more potent in producing sedation than analgesia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
151
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Objective assessment of detomidine-induced analgesia and sedation in the horse.
pubmed:affiliation
Department of Veterinary Physiology, Pharmacology and Toxicology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't