| pubmed-article:3416897 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3416897 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3416897 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3416897 | lifeskim:mentions | umls-concept:C1272575 | lld:lifeskim |
| pubmed-article:3416897 | lifeskim:mentions | umls-concept:C0013089 | lld:lifeskim |
| pubmed-article:3416897 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:3416897 | lifeskim:mentions | umls-concept:C0743223 | lld:lifeskim |
| pubmed-article:3416897 | lifeskim:mentions | umls-concept:C0050885 | lld:lifeskim |
| pubmed-article:3416897 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:3416897 | pubmed:dateCreated | 1988-10-17 | lld:pubmed |
| pubmed-article:3416897 | pubmed:abstractText | The localization of cardiac cytofluorescence and tissue levels of doxorubicin (DXR) and doxorubicinol (DXR-ol) were studied in rats treated with a single (9 mg/kg: 1-day study) or 3 weekly doses (3 mg/kg: 7-week study) of the compounds. A striking orange-red fluorescence was observed in cardiac cell nuclei from DXR 1-day rats, whilst heart cells from DXR-ol 1-day rats displayed a faint, diffuse fluorescence. Neither cardiac tissue from DXR nor from DXR-ol 7-week animals showed any drug-specific fluorescence. HPLC assay showed that in DXR 1-day rats the drug was concentrated in the heart, which also contained the endogenously produced DXR-ol. Plasma levels of DXR-ol were initially high in DXR-ol 1-day rats but rapidly decreased with time; cardiac levels of DXR-ol remained low. Hearts from DXR 7-week rats contained appreciable amounts of DXR and DXR-ol, while very low levels of DXR-ol were found in DXR-ol 7-week animals. The data correlated well with the ECG alterations recorded during the study, which were more severe in DXR- than in DXR-ol-treated rats. These results indicate that the lower tissue uptake of exogenously administered DXR-ol might explain its lower toxic cardiac potential compared with DXR. | lld:pubmed |
| pubmed-article:3416897 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3416897 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3416897 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3416897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3416897 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3416897 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3416897 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:3416897 | pubmed:issn | 0277-5379 | lld:pubmed |
| pubmed-article:3416897 | pubmed:author | pubmed-author:Del TaccaMM | lld:pubmed |
| pubmed-article:3416897 | pubmed:author | pubmed-author:PaparelliAA | lld:pubmed |
| pubmed-article:3416897 | pubmed:author | pubmed-author:DanesiRR | lld:pubmed |
| pubmed-article:3416897 | pubmed:author | pubmed-author:BernardiniNN | lld:pubmed |
| pubmed-article:3416897 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3416897 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:3416897 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3416897 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3416897 | pubmed:pagination | 1123-31 | lld:pubmed |
| pubmed-article:3416897 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
| pubmed-article:3416897 | pubmed:meshHeading | pubmed-meshheading:3416897-... | lld:pubmed |
| pubmed-article:3416897 | pubmed:meshHeading | pubmed-meshheading:3416897-... | lld:pubmed |
| pubmed-article:3416897 | pubmed:meshHeading | pubmed-meshheading:3416897-... | lld:pubmed |
| pubmed-article:3416897 | pubmed:meshHeading | pubmed-meshheading:3416897-... | lld:pubmed |
| pubmed-article:3416897 | pubmed:meshHeading | pubmed-meshheading:3416897-... | lld:pubmed |
| pubmed-article:3416897 | pubmed:meshHeading | pubmed-meshheading:3416897-... | lld:pubmed |
| pubmed-article:3416897 | pubmed:meshHeading | pubmed-meshheading:3416897-... | lld:pubmed |
| pubmed-article:3416897 | pubmed:meshHeading | pubmed-meshheading:3416897-... | lld:pubmed |
| pubmed-article:3416897 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3416897 | pubmed:articleTitle | Cytofluorescence localization and disposition of doxorubicin and doxorubicinol in rat cardiac tissue. | lld:pubmed |
| pubmed-article:3416897 | pubmed:affiliation | Institute of Medical Pharmacology, University of Pisa, Italy. | lld:pubmed |
| pubmed-article:3416897 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3416897 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3416897 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3416897 | lld:pubmed |
