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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
1988-10-21
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pubmed:abstractText |
Specific features of 2-ethyl-6-methyl-3-hydroxypyridine (3-OP) action were investigated in white rats. A correlation has been established between pharmacokinetic parameters and basic manifestations of psychotropic 3-OP effect. Correlations have been also observed between the level of manifestation of anxiolytic effect and changes in 3-OP concentrations in the rat brain. Electroencephalographic findings of the nootropic effect in sensorimotor cortex correlate with 3-OP brain concentrations. The authors describe specific drug pharmacokinetics and possible mechanisms of realization of psychotropic effects.
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pubmed:language |
rus
|
pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0365-9615
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
106
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
165-7
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pubmed:dateRevised |
2008-10-8
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pubmed:meshHeading |
pubmed-meshheading:3416050-Animals,
pubmed-meshheading:3416050-Behavior, Animal,
pubmed-meshheading:3416050-Brain,
pubmed-meshheading:3416050-Conflict (Psychology),
pubmed-meshheading:3416050-Electroencephalography,
pubmed-meshheading:3416050-Electrophysiology,
pubmed-meshheading:3416050-Liver,
pubmed-meshheading:3416050-Male,
pubmed-meshheading:3416050-Picolines,
pubmed-meshheading:3416050-Plasma,
pubmed-meshheading:3416050-Psychotropic Drugs,
pubmed-meshheading:3416050-Rats,
pubmed-meshheading:3416050-Time Factors
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pubmed:year |
1988
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pubmed:articleTitle |
[Pharmacokinetic, behavioral and neurophysiological aspects of the action of 2-ethyl-6-methyl-3-hydroxypyridine in rats].
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pubmed:publicationType |
Journal Article,
English Abstract
|