Linked Life Data

3414976

Source:http://linkedlifedata.com/resource/pubmed/id/3414976

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-10-11
pubmed:abstractText
We examined the role of thyroid hormone (TH) in mediating cranial ossification during metamorphosis in the Oriental fire-bellied toad, Bombina orientalis. Exogenous T3 (3,3',5-triiodo-L-thyronine) was administered in three treatment dosages (0.025, 0.25, and 2.5 micrograms) plus a control dosage via plastic micropellets implanted within the dermis of tadpoles of three Gosner developmental stages: 28/29, 30/31, 32/33. Tadpoles were recovered after 2, 4, 6, and 8 d, and scored for the presence of three bones - median parasphenoid and paired frontoparietals and exoccipitals--as seen in cleared-and-stained, whole-mount preparations. T3 induced precocious ossification in both a stage-dependent and a dosage-dependent manner; stage dependence corresponded precisely with the degree of osteogenic differentiation at the time of hormone administration. Precocious ossification thus was due to the T3-promoted growth and calcified matrix deposition of these centers. Differential TH sensitivity among osteogenic sites may underlie both the temporal cranial ossification sequences characteristic of metamorphosing amphibians as well as sequence differences commonly observed among taxa.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-2061
pubmed:author
pubmed:issnType
Print
pubmed:volume
178
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-27
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Skull development during anuran metamorphosis. II. Role of thyroid hormone in osteogenesis.
pubmed:affiliation
Department of Environmental, Population, and Organismic Biology, University of Colorado, Boulder 80309-0334.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't