Linked Life Data

3414324

Source:http://linkedlifedata.com/resource/pubmed/id/3414324

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-10-13
pubmed:abstractText
The biological and morphological effects of cis-tamoxifen, N-desmethyltamoxifen and 4-hydroxy-tamoxifen, administered sc alone (100 micrograms/animal) or combined with estradiol (20 micrograms/animal) were studied in the uterus and vagina of the guinea pig. After 2 days treatment the values of the uterine wet weights (mg +/- SD of 6-10 animals in each study) were as follows: non-treated animals (control): 142 +/- 15; animals treated with cis-tamoxifen: 119 +/- 4; N-desmethyltamoxifen: 280 +/- 20; 4-hydroxytamoxifen: 268 +/- 25. The values after long treatment were: 177 +/- 30; 490 +/- 65; 394 +/- 36 and 581 +/- 60, respectively. After short treatment the weights of the vaginas were: control: 99 +/- 20; cis-Tamoxifen: 67 +/- 2; N-desmethyltamoxifen: 153 +/- 25; 4-hydroxytamoxifen: 166 +/- 7; and after the long treatment: 155 +/- 40; 660 +/- 41; 467 +/- 38 and 502 +/- 61, respectively. N-desmethyltamoxifen and 4-hydroxytamoxifen increased the progesterone receptors in the uterus after short treatment (P less than 0.01) but not after 12 days treatment. On the other hand, there was no effect on progesterone receptor in the vagina after the short treatment but a very stimulatory effect after the long treatment. The morphological alterations after 12-days treatment indicate that the three tamoxifen derivatives in the two tissues studied provoke intense alterations in different organelles. In conclusion, it is suggested that the tamoxifen derivatives can act as real agonists in the uterus and vagina of the newborn guinea pig, and they do not block the effect provoked by estradiol.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0001-5598
pubmed:author
pubmed:issnType
Print
pubmed:volume
119
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
85-90
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Biological effects and ultrastructural alterations of cis-tamoxifen, N-desmethyltamoxifen and 4-hydroxytamoxifen in the uterus and vagina of newborn guinea pigs.
pubmed:affiliation
C.N.R.S. Steroid Hormone Research Unit, Foundation for Hormone Research, Paris, France.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't