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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4870
|
pubmed:dateCreated |
1988-10-5
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pubmed:databankReference | |
pubmed:abstractText |
Transcription of zygotic genes does not occur in early Xenopus embryos until the mid-blastula transition, 6 to 7 hours after fertilization. Before this time, development is directed by maternal proteins and messenger RNAs stored within the egg. Two different forms of the A chain of platelet-derived growth factor (PDGF) are shown here to be encoded by maternal messenger RNAs. The two forms closely resemble human PDGF; however, the long form contains a hydrophobic region near the carboxyl terminus. The presence of PDGF messenger RNA in the embryo supports the idea that endogenous growth factors act at the earliest stages of embryogenesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Sep
|
pubmed:issn |
0036-8075
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
2
|
pubmed:volume |
241
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1223-5
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:3413486-Amino Acid Sequence,
pubmed-meshheading:3413486-Animals,
pubmed-meshheading:3413486-Base Sequence,
pubmed-meshheading:3413486-Blastocyst,
pubmed-meshheading:3413486-DNA,
pubmed-meshheading:3413486-Gastrula,
pubmed-meshheading:3413486-Humans,
pubmed-meshheading:3413486-Molecular Sequence Data,
pubmed-meshheading:3413486-Nucleic Acid Hybridization,
pubmed-meshheading:3413486-Oocytes,
pubmed-meshheading:3413486-Platelet-Derived Growth Factor,
pubmed-meshheading:3413486-RNA, Messenger,
pubmed-meshheading:3413486-Xenopus laevis
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pubmed:year |
1988
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pubmed:articleTitle |
Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos.
|
pubmed:affiliation |
Dana-Farber Cancer Institute, Boston, MA.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|