|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0005528,
umls-concept:C0016491,
umls-concept:C0017725,
umls-concept:C0022378,
umls-concept:C0085862,
umls-concept:C0085979,
umls-concept:C0596901,
umls-concept:C1299583,
umls-concept:C1549571,
umls-concept:C1608386,
umls-concept:C1709059
|
|
pubmed:issue |
17
|
|
pubmed:dateCreated |
1988-10-6
|
|
pubmed:abstractText |
D-glucose transport across the intestinal brush-border membrane involves two transport systems designated here as systems 1 and 2. Kinetic properties for both D-glucose and methyl alpha-D-glucopyranoside transport were measured at 35 degrees C by using brush-border membrane vesicles prepared from either control, fasted (48 hr), or semistarved (10 days) animals. The results show the following: (i) The sugar influx rate by simple diffusion was identical under either altered condition. (ii) Semistarvation stimulated D-glucose uptake by system 2 (both its Vmax and Km increased), whereas system 1 was untouched. (iii) Fasting increased the capacity of system 1 without affecting either Km of system 1 or Vmax and Km of system 2. The effect of fasting on Vmax of system 1 cannot be attributed to indirect effects from changes in ionic permeability because the kinetic difference between control and fasted animals persisted when the membrane potential was short-circuited with equilibrated K+ and valinomycin. This work provides further evidence for the existence of two distinct sodium-activated D-glucose transport systems in the intestinal brush-border membrane, which adapt independently to either semistarvation or fasting.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-1206572,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-3084480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-322241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-3575088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-3663668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-45778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-4692832,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-49051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-5448196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-6030513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-6353941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-6383475,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-6432045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-6436478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-6776986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-7346624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413102-80978
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
85
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6370-3
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:3413102-Animals,
pubmed-meshheading:3413102-Diet,
pubmed-meshheading:3413102-Eating,
pubmed-meshheading:3413102-Female,
pubmed-meshheading:3413102-Glucose,
pubmed-meshheading:3413102-Guinea Pigs,
pubmed-meshheading:3413102-Jejunum,
pubmed-meshheading:3413102-Kinetics,
pubmed-meshheading:3413102-Microvilli,
pubmed-meshheading:3413102-Monosaccharide Transport Proteins,
pubmed-meshheading:3413102-Sodium,
pubmed-meshheading:3413102-Starvation
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Independent modulation by food supply of two distinct sodium-activated D-glucose transport systems in the guinea pig jejunal brush-border membrane.
|
|
pubmed:affiliation |
Centre de Recherches sur la Nutrition, Meudon, France.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
