|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16
|
|
pubmed:dateCreated |
1988-10-5
|
|
pubmed:abstractText |
Replacement of the solvent-exposed residues of the DNA recognition helix of the 434 repressor with the corresponding residues of the P22 repressor generates a hybrid protein, 434R[alpha 3(P22R)], which binds specifically to P22 operators. We show here that a new DNA-binding specificity is generated by combining 434 and 434R[alpha 3(P22R)] repressor monomers to form a heterodimer. The heterodimer specifically recognizes a chimeric P22/434 operator that lacks two-fold rotational symmetry.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-159452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-2826015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-2985470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-3280141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-3304657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-3553959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-3553961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-3881765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-3887184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-3996185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-4033758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-4938552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-6236744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-6300771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-6369323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-6445008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-6540625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3413061-6757864
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
85
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
5834-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
A repressor heterodimer binds to a chimeric operator.
|
|
pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Harvard University, Cambridge, MA 02138.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
