Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-10-13
pubmed:abstractText
A cytogenetical analysis of chromosomal aberrations, sister chromatid exchanges (SCEs), C-band heteromorphisms and nucleolar organizer regions was done in lymphocytes of 30 patients with precancerous lesions of the uterine cervix progressed to carcinoma and of 30 patients with nonprogressed lesions in a period of 60 months follow-up, in order to identify if any differences existed between low-risk and high-risk dysplasias. Increased frequency of chromosomal breaks, SCEs and C-band heteromorphisms of chromosome 1 and decreased activity of ribosomal genes was observed in patients with dysplasias progressed to carcinoma compared to that of nonprogressed precancerous lesions. The present study thus suggests an intimate relationship between the constitutional chromosomal phenotypes and development of cancer, and these may serve as useful biological markers in defining dysplasias at high risk to progress to cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0030-2414
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
384-8
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Chromosomal phenotypes in patients with precancerous lesions of the uterine cervix progressed to cancer during follow-up.
pubmed:affiliation
Cytology Research Center, Maulana Azad Medical College, New Delhi, India.
pubmed:publicationType
Journal Article