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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
13
|
| pubmed:dateCreated |
1988-10-11
|
| pubmed:abstractText |
We performed echocardiography prospectively 4.9 +/- 0.7 years apart (mean +/- SD), in 74 patients with systemic lupus erythematosus. On the basis of the first study, the patients were distributed in four groups according to the type of valvular involvement: 7 patients had vegetations (Libman-Sacks endocarditis; group 1); 6 patients had rigid and thickened valves with stenosis, regurgitation, or both (group 2); 5 patients had miscellaneous forms of valvular involvement without valvular dysfunction (group 3), as did the 60 controls; and 56 patients had no valvular disease (group 4). The overall prevalence of clinically important valvular disease (groups 1 and 2) was 18 percent. Patients in group 1 were younger than those in group 2 (33.5 +/- 16.7 vs. 47.8 +/- 17.6 years; P less than 0.05), had a shorter mean duration of lupus (4.8 +/- 2.2 vs. 10.7 +/- 6.4 years; P less than 0.001), and had received a smaller cumulative dose of steroids (21.5 +/- 13.1 vs. 79.5 +/- 63.4 g of methylprednisolone or its equivalent; P less than 0.05). During the five-year follow-up, one patient in group 1 and five in group 2 required valve surgery, no patient in group 3 had valvular dysfunction, and five patients in group 4 had mild valvular lesions. We conclude that clinically important valvular involvement in systemic lupus is relatively frequent and sometimes requires surgery. Echocardiography can identify a subset of lesions (valvular thickening and dysfunction), other than verrucous (Libman-Sacks) endocarditis, that are prone to hemodynamic deterioration.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0028-4793
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
29
|
| pubmed:volume |
319
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
817-23
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3412413-Adolescent,
pubmed-meshheading:3412413-Adult,
pubmed-meshheading:3412413-Age Factors,
pubmed-meshheading:3412413-Aged,
pubmed-meshheading:3412413-Echocardiography,
pubmed-meshheading:3412413-Endocarditis,
pubmed-meshheading:3412413-Female,
pubmed-meshheading:3412413-Follow-Up Studies,
pubmed-meshheading:3412413-Heart Valve Diseases,
pubmed-meshheading:3412413-Humans,
pubmed-meshheading:3412413-Lupus Erythematosus, Systemic,
pubmed-meshheading:3412413-Male,
pubmed-meshheading:3412413-Methylprednisolone,
pubmed-meshheading:3412413-Middle Aged,
pubmed-meshheading:3412413-Prospective Studies,
pubmed-meshheading:3412413-Time Factors
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Prevalence, morphologic types, and evolution of cardiac valvular disease in systemic lupus erythematosus.
|
| pubmed:affiliation |
Servicio de Cardiología, Hospital General Vall d'Hebron, Barcelona, Spain.
|
| pubmed:publicationType |
Journal Article
|