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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1988-10-11
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pubmed:abstractText |
Diastereomeric para-substituted dichloro(1,2-diphenylethylenediamine)platinum(II) complexes were synthesized and tested for their antitumor activity on the human MDA-MB 231 breast cancer cell line and the P 388 leukemia of the mouse. An interaction with the DNA was demonstrated by UV difference spectroscopy. The D,L configurated, 4-fluoro-substituted complex was the most active.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:issn |
0171-5216
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
114
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
347-58
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3410875-Animals,
pubmed-meshheading:3410875-Antineoplastic Agents,
pubmed-meshheading:3410875-Breast Neoplasms,
pubmed-meshheading:3410875-Carcinoma, Ehrlich Tumor,
pubmed-meshheading:3410875-Cell Line,
pubmed-meshheading:3410875-Drug Screening Assays, Antitumor,
pubmed-meshheading:3410875-Humans,
pubmed-meshheading:3410875-Leukemia P388,
pubmed-meshheading:3410875-Organoplatinum Compounds,
pubmed-meshheading:3410875-Stereoisomerism,
pubmed-meshheading:3410875-Structure-Activity Relationship
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pubmed:year |
1988
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|
pubmed:articleTitle |
Influence of ring substituents on the antitumor effect of dichloro(1,2-diphenylethylenediamine)platinum(II) complexes.
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pubmed:affiliation |
Institut für Pharmazie, Lehrstuhl Pharmazeutische Chemie II, Regensburg, Federal Republic of Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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