Linked Life Data

3410283

Source:http://linkedlifedata.com/resource/pubmed/id/3410283

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1988-10-6
pubmed:abstractText
1. Acute effects of an antiarrhythmic agent, amiodarone (AM), on action potentials from isolated guinea-pig ventricular papillary muscles exposed to simulated ischemic solution and Tyrode's solution containing NaCN or dinitrophenol (DNP) were examined. 2. In the papillary muscles exposed to simulated solution (K+ = 6 mM, glucose = 2.3 mM, pH = 7.1, PO2 less than 40 mmHg) or metabolic inhibitors (10(-3) M NaCN or 10(-4) M DNP), resting membrane potential (RMP) and maximum upstroke velocity (Vmax) of action potential were decreased with increasing time to the exposure, and action potential duration (APD) was shortened. In these conditions, addition of 4.4 x 10(-5) M AM produced transient and small increase in the APD and Vmax, followed by progressive APD-shortening and decrease in Vmax and RMP. 3. These results suggest that acute AM's antiarrhythmic effects reported are not due to APD prolonging action (Vaughan Williams Class III) of the drug, but mainly due to its local anesthetic action (Class I).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-3623
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
609-13
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Acute effects of amiodarone on action potentials of isolated guinea-pig ventricular muscle exposed to simulated ischemic solution and metabolic inhibitors.
pubmed:affiliation
Department of Medicine, Northwestern University Medical School, Chicago, IL 60611.
pubmed:publicationType
Journal Article