Linked Life Data

3409962

Source:http://linkedlifedata.com/resource/pubmed/id/3409962

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-10-5
pubmed:abstractText
Yohimbine (1 mg/kg s.c.) produced significant and persistent increases in plasma renin concentration and plasma norepinephrine concentration in conscious rats, but mean arterial pressure (MAP) and heart rate were unchanged. The subsequent i.v. infusion of the angiotensin II receptor antagonist saralasin (100 micrograms/kg per min) caused a significant decrease (-17%) in MAP. We conclude that yohimbine-induced renin release, and the resultant rise in plasma angiotensin II concentration, prevents the decrease in MAP which would result from the blockade of vascular alpha-adrenoceptors by yohimbine.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
149
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
377-80
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Angiotensin II contributes to blood pressure maintenance in conscious rats treated with yohimbine.
pubmed:affiliation
Department of Pharmacology, University of Texas Health Science Center, San Antonio 78284.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.