Linked Life Data

3409957

Source:http://linkedlifedata.com/resource/pubmed/id/3409957

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-10-5
pubmed:abstractText
3,4-Diaminopyridine, a potassium (K+) channel blocker, was used to induce phasic contractions in an isolated K+-contracted dog left anterior descending coronary artery ring preparation. The effects of adenosine, N6-L-phenyl-isopropyl-adenosine (L-PIA) and 5'-N-ethylcarboxamide-adenosine (NECA) were compared with those of calcium (Ca2+) entry blockers (nifedipine, verapamil, diltiazem) on the maximum developed force, minimum developed force and contraction frequency in this model. Adenosine, L-PIA and NECA significantly relaxed the minimum force and decreased the contraction frequency without any effect on the maximum force. The order of potency was: NECA greater than L-PIA greater than adenosine. Nifedipine, verapamil and diltiazem significantly relaxed the maximum force and increased the contraction frequency without a significant relaxing effect on minimum force. It is, therefore, likely that adenosine (and its analogs) and Ca2+ entry blockers have different mechanisms for the relaxation of coronary smooth muscle and that adenosine probably relaxes the vessels through A2 receptor.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
10
pubmed:volume
149
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
345-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effects of adenosine and calcium entry blockers on 3,4-diaminopyridine-induced rhythmic contractions in dog coronary artery.
pubmed:affiliation
Department of Pharmacology, School of Medicine, East Carolina University, Greenville, NC 27834.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.