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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1988-10-11
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pubmed:abstractText |
The ELH prohormone is proteolytically processed into at least nine peptides which govern egg-laying behavior in Aplysia. Quantitative immunocytochemistry demonstrates that peptides derived from the prohormone are packaged into distinct vesicle classes. Further experiments suggest the segregation occurs via a rapid initial proteolytic cleavage of the prohormone followed by sorting at the trans Golgi. Egg-laying hormone (ELH) immunoreactivity is localized to the cell body and processes, while bag cell peptide (BCP) immunoreactivity is greater in the cell body. Steady state levels of the amino-terminal set of peptides including the BCPs are 3- to 8-fold lower than the carboxy-terminal cleavage products, such as ELH. Thus, intracellular packaging and routing of the peptides cleaved from a single prohormone regulate their localization and levels in these neurons.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0092-8674
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
813-22
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3409320-Animals,
pubmed-meshheading:3409320-Aplysia,
pubmed-meshheading:3409320-Biological Transport,
pubmed-meshheading:3409320-Cell Compartmentation,
pubmed-meshheading:3409320-Cytoplasmic Granules,
pubmed-meshheading:3409320-Immunohistochemistry,
pubmed-meshheading:3409320-Invertebrate Hormones,
pubmed-meshheading:3409320-Microscopy, Electron,
pubmed-meshheading:3409320-Neurons,
pubmed-meshheading:3409320-Protein Precursors,
pubmed-meshheading:3409320-Protein Processing, Post-Translational
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pubmed:year |
1988
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pubmed:articleTitle |
Multiple neuropeptides derived from a common precursor are differentially packaged and transported.
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pubmed:affiliation |
Department of Biological Sciences, Stanford University, California 94305.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|