Linked Life Data

3407271

Source:http://linkedlifedata.com/resource/pubmed/id/3407271

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1988-9-22
pubmed:abstractText
In 14 patients with various kinds of cardiomyopathy (DCM, HCM with and without obstruction, latent cardiomyopathy (= LCM], after confirmation of diagnosis, myocardial imaging with the recently developed substance 123I-metaiodobenzylguanidine (MIBG), an analog to guanethidine, was performed. In comparison, four patients in whom cardiac disease had been excluded, were evaluated. Myocardial uptake and washout were evaluated quantitatively. As a result, each kind of cardiomyopathy showed a significantly higher activity uptake versus normals, especially in patients with DCM. In all patients, the washout rate was increased compared to normals. The higher uptake is caused by depletion of catecholamine stores, as already known in DCM. On the other hand, the increased washout rate is considered to be a sign of a high sympathetic tone found in patients with HCM and LCM. The results seem to demonstrate a primary or secondary involvement of the sympathetic nervous system in these entities of hitherto unknown etiology.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0300-5860
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
278-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
[Scintigraphic imaging of adrenergic structures of the heart with 123(I)-metaiodobenzylguanidine in cardiomyopathy].
pubmed:affiliation
Medizinische Universitätsklinik II, Städtische Krankenanstalten Köln-Merheim.
pubmed:publicationType
Journal Article, English Abstract