Linked Life Data

3404976

Source:http://linkedlifedata.com/resource/pubmed/id/3404976

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-9-13
pubmed:abstractText
In this paper we describe two simple experimental models of diffuse interstitial renal fibrosis in the rat. One develops 25 days after unilateral renal vein ligation, and the other 15 days after unilateral ureteral double ligation and section. In both models fibrosis is examined morphologically and biochemically, the latter with emphasis on collagen turnover. In addition to a description of the histology, also presented are quantitative biochemical data on four features of tissue collagen turnover, namely total content, concentration, biosynthesis, and degradation. Although the microscopic picture of both models can be adequately described as interstitial diffuse renal fibrosis, their mechanisms are different: unilateral renal vein ligation is an example of collapse fibrosis, whereas unilateral ureteral double ligation and section is a model of absolute fibrosis. In both models however, decreased collagen degradation is the significant metabolic abnormality.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0023-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
245-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Experimental diffuse interstitial renal fibrosis. A biochemical approach.
pubmed:affiliation
Subdivision de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, México City.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't