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rdf:type |
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lifeskim:mentions |
umls-concept:C0021641,
umls-concept:C0026845,
umls-concept:C0028754,
umls-concept:C0086418,
umls-concept:C0178666,
umls-concept:C0205216,
umls-concept:C0280606,
umls-concept:C0412467,
umls-concept:C0681850,
umls-concept:C1521827,
umls-concept:C1533691,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C1948023,
umls-concept:C2349001,
umls-concept:C2697811
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pubmed:issue |
2
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pubmed:dateCreated |
1988-9-20
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pubmed:abstractText |
We have developed an in vitro muscle preparation suitable for metabolic studies with human muscle tissue and have investigated the effects of obesity and non-insulin-dependent diabetes mellitus (NIDDM) on glucose transport. Transport of 3-O-methylglucose and 2-deoxyglucose was stimulated approximately twofold by insulin in muscle from normal nonobese subjects and stimulation occurred in the normal physiological range of insulin concentrations. In contrast to insulin stimulation of 3-O-methylglucose and 2-deoxyglucose transport in muscle from normal, nonobese subjects, tissue from morbidly obese subjects, with or without NIDDM, were not responsive to insulin. Maximal 3-O-methylglucose transport was lower in muscle of obese than nonobese subjects. Morbidly obese patients, with or without NIDDM, have a severe state of insulin resistance in glucose transport. The novel in vitro human skeletal muscle preparation herein described should be useful in investigating the mechanism of this insulin resistance.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-13972875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-2865274,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-3032715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-3033021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-3294899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-3307452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-3308958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-3512959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-3522628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-3894418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-3898862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-3901744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-4260388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-6148358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-6369971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-6456276,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-6749903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-6761196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-6990920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-6997333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-7008628,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-7026616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-7030834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3403714-7077000
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
82
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
486-94
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3403714-3-O-Methylglucose,
pubmed-meshheading:3403714-Adult,
pubmed-meshheading:3403714-Biological Transport,
pubmed-meshheading:3403714-Deoxyglucose,
pubmed-meshheading:3403714-Diabetes Mellitus, Type 2,
pubmed-meshheading:3403714-Female,
pubmed-meshheading:3403714-Glucose,
pubmed-meshheading:3403714-Glucose Tolerance Test,
pubmed-meshheading:3403714-Humans,
pubmed-meshheading:3403714-Insulin Resistance,
pubmed-meshheading:3403714-Male,
pubmed-meshheading:3403714-Methylglucosides,
pubmed-meshheading:3403714-Muscles,
pubmed-meshheading:3403714-Obesity, Morbid,
pubmed-meshheading:3403714-Time Factors
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pubmed:year |
1988
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pubmed:articleTitle |
An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects.
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pubmed:affiliation |
Department of Biochemistry, School of Medicine, East Carolina University, Greenville, North Carolina 27858.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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