Linked Life Data

3402535

Source:http://linkedlifedata.com/resource/pubmed/id/3402535

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1988-9-16
pubmed:abstractText
The effects of the vasodilating dihydropyridine, felodipine, on tissue concentrations of high-energy phosphates and on oxygen consumption and lactate production in the smooth muscle of the rat portal vein were investigated. Felodipine (100 nM) caused a gradual decrease in the amplitude of the spontaneous phasic contractions in a calcium-containing medium. The mean active force was reduced by about 80% within 15 min. The inhibition of force was associated with reductions in both oxygen consumption and lactate production. No effects of felodipine could be observed in a calcium-free solution. The metabolic rates and force during felodipine inhibition approached those recorded in the calcium-free media. Felodipine (30 nM) did not alter the tissue levels of ATP, ADP, AMP and phosphocreatine. Relaxation by felodipine is thus associated with a decreased energy demand for contraction and, possibly, ionic translocation. The reduced ATP hydrolysis is compensated for by the regeneration of metabolic ATP, thus keeping the cellular levels of high-energy phosphates constant.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
20
pubmed:volume
150
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-22
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effects of felodipine on energy turnover in the rat portal vein.
pubmed:affiliation
Department of Physiology and Biophysics, University of Lund, Sweden.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't