Linked Life Data

3401707

Source:http://linkedlifedata.com/resource/pubmed/id/3401707

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1988-9-15
pubmed:abstractText
We have recently described a system, using dispersed chick pineal cells in static culture, which displays a persistent, photosensitive, circadian rhythm of melatonin release, and the effects of light upon it. Here we describe the effects of norepinephrine (NE) on melatonin output by these cells. NE inhibited nocturnal melatonin release; it was potent and effective. Pertussis toxin, forskolin, or 8-Br-cAMP blocked or circumvented inhibition by NE, suggesting the involvement of adenylate cyclase. Four hour pulses of NE caused acute suppression of melatonin output, but did not affect the phase of subsequent cycles in constant red light. These results indicate that NE affects melatonin production by mechanisms acting distal to the pacemaker which generates the melatonin rhythm. Insofar as adenylate cyclase appears to be involved in the action of NE, it might be involved in the regulation of melatonin output by the pacemaker, but is not implicated in regulation of the pacemaker by light.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
450
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
137-43
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Norepinephrine, acting via adenylate cyclase, inhibits melatonin output but does not phase-shift the pacemaker in cultured chick pineal cells.
pubmed:affiliation
Laboratory of Cell Biology, NIMH, Bethesda, MD 20892.
pubmed:publicationType
Journal Article