Linked Life Data

3401560

Source:http://linkedlifedata.com/resource/pubmed/id/3401560

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1988-9-21
pubmed:abstractText
Using neurohistological and cytochemical methods in the living cells, the peculiarities of the action of endogenous neurotoxin, quinolinic acid (QUIN), on the neurons developing in the cell cultures of the hippocamp, neocortex and septum have been investigated in 17-19-day-old mouse embryos. The addition of 500 microM of QUIN on the 21st--22nd day into the nutrition medium in vitro resulted in the rapid destruction of neurons localized in glioneuronal aggregates, while the isolated nervous cells as well as septal cholinergic neurons remained intact. At earlier stages of cultivation (up to 2 weeks) QUIN did not provoke degenerative changes in the cultivated neurons. The comparison of our results with the literary data suggests that in nervous cell cultures QUIN, having mature synaptic connections with afferent nervous fibers, causes destruction of neurons.
pubmed:language
rus
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0365-9615
pubmed:author
pubmed:issnType
Print
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-6
pubmed:dateRevised
2008-10-8
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
[Effect of quinolinic acid on neurons in dissociated cultures of cells of different structures of the brain].
pubmed:publicationType
Journal Article, In Vitro, English Abstract