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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1988-9-1
|
| pubmed:abstractText |
High-affinity (3H)choline uptake was compared in cultured skin fibroblasts derived from 15 normal volunteers and 21 unrelated individuals with primary childhood-onset dystonia. Dystonia cell lines did not differ significantly from the control cell lines, regardless of whether they were derived from individuals exhibiting a positive or negative response to anticholinergic drug therapy. The analysis was extended to members of a large non-Jewish kindred characterized by apparent autosomal dominant inheritance of dystonia. The rate of high-affinity [3H]choline uptake in cells from the affected members of the family did not differ significantly from that measured in the cell lines from unaffected individuals. The results suggest that a generalized cellular defect in high-affinity choline uptake is not involved in the pathogenesis of dystonia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0091-3952
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
50
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
183-6
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading | |
| pubmed:year |
1988
|
| pubmed:articleTitle |
High-affinity choline uptake in cultured skin fibroblasts from individuals with dystonia.
|
| pubmed:affiliation |
Department of Neurology, College of Physicians & Surgeons, Columbia University, New York, New York 10032.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|