Linked Life Data

3399618

Source:http://linkedlifedata.com/resource/pubmed/id/3399618

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-9-6
pubmed:abstractText
Cessation of lactation, initiated by the removal of lambs from their mothers, induced an inflammatory response with elevated numbers of neutrophil leucocytes in mammary secretions being detected within 16 h. Leucocyte numbers were still elevated 7 d later. Infusion of whole milk into non-lactating glands caused no change in leucocyte numbers after 24 h. Involution secretions, however, had the capacity to induce an inflammatory response when infused into non-lactating glands. Daily infusion of endotoxin (100 ng) into non-lactating glands resulted in a marked attenuation of the inflammatory response. Such desensitization did not accompany reinfusion of involution secretion. Responses to involution secretion were enhanced in glands desensitized to endotoxin. The failure of desensitization to develop in glands receiving repeated infusions of involution secretion and the lack of cross-desensitization between involution secretion and endotoxin indicate that a novel mediator of inflammation may be produced during mammary involution in sheep.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0144-8757
pubmed:author
pubmed:issnType
Print
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
363-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Studies on the inflammatory response during involution of the ovine mammary gland.
pubmed:affiliation
CSIRO Division of Animal Health, Armidale, N.S.W., Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't