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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6179
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pubmed:dateCreated |
1988-8-30
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pubmed:databankReference | |
pubmed:abstractText |
The CTF/NF-I group of cellular DNA binding proteins recognizes the sequence GCCAAT and is implicated in eukaryotic transcription as well as DNA replication. Molecular analysis of human CTF/NF-I complementary DNA clones reveals multiple messenger RNA species containing alternative coding regions, apparently as a result of differential splicing. Expression and functional analysis establish that individual gene products can bind to GCCAAT recognition sites and serve both as promoter-selective transcriptional activators and as initiation factors for DNA replication.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0028-0836
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
334
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
218-24
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:3398920-Adenoviridae,
pubmed-meshheading:3398920-Amino Acid Sequence,
pubmed-meshheading:3398920-Base Sequence,
pubmed-meshheading:3398920-Cloning, Molecular,
pubmed-meshheading:3398920-DNA,
pubmed-meshheading:3398920-DNA Replication,
pubmed-meshheading:3398920-DNA-Binding Proteins,
pubmed-meshheading:3398920-Humans,
pubmed-meshheading:3398920-Molecular Sequence Data,
pubmed-meshheading:3398920-Promoter Regions, Genetic,
pubmed-meshheading:3398920-RNA Polymerase II,
pubmed-meshheading:3398920-RNA Splicing,
pubmed-meshheading:3398920-Transcription, Genetic,
pubmed-meshheading:3398920-Transcription Factors,
pubmed-meshheading:3398920-Virus Replication
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pubmed:year |
1988
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pubmed:articleTitle |
A family of human CCAAT-box-binding proteins active in transcription and DNA replication: cloning and expression of multiple cDNAs.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biochemistry, University of California, Berkeley.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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