Linked Life Data

3396414

Source:http://linkedlifedata.com/resource/pubmed/id/3396414

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-9-2
pubmed:abstractText
We studied lung collagen metabolism in 18 patients with hypersensitivity pneumonitis to determine if changes at this level could explain the different clinical courses followed by these patients. Collagen concentration, biosynthesis and degradation were measured in lung tissue samples obtained before treatment. Four patients healed, eight improved and six did not improve or worsened. All patients who healed showed an important increase in collagenolysis; patients who improved had normal or high values, but significantly less than those obtained in patients who healed. Finally, five out of the six patients who did not improve or worsened had a significant decrease in degradation. These findings support the notion that a diminution of local collagenolysis may play a role in the progression to fibrosis in some patients with hypersensitivity pneumonitis and can also be a useful tool to predict the prognosis of this disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0012-3692
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
347-53
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Lung collagen metabolism and the clinical course of hypersensitivity pneumonitis.
pubmed:affiliation
Clinical Research Division, Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.
pubmed:publicationType
Journal Article