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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1988-9-7
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pubmed:abstractText |
1. Tritium labelled oestradiol-3 beta-D-glucuronide (E2-3G) was synthesised by sodium borohydride reduction of labelled oestrone-glucuronide (E1-G) and injected intravenously into anaesthetised rats. Bile and urine were collected to assess the routes and rate of excretion of E2-3G. Bile and urine samples were analysed by reverse phase HPLC to determine the metabolites of E2-3G. 2. When E2-3G was given at 11 and 22 mumol/kg, 83 and 85% respectively was excreted in bile within 3 hr and 1 and 3% in urine. 3. The major metabolite was E1-G which accounted for 89 and 92% respectively of the injected E2-3G which was recovered in bile. 4. It is concluded that bile is the major route of excretion of E2-3G in rats and that it is converted mainly to E1-G before excretion.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0305-0491
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
90
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
99-101
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3396334-Animals,
pubmed-meshheading:3396334-Bile,
pubmed-meshheading:3396334-Chromatography, High Pressure Liquid,
pubmed-meshheading:3396334-Estradiol,
pubmed-meshheading:3396334-Female,
pubmed-meshheading:3396334-Rats,
pubmed-meshheading:3396334-Rats, Inbred Strains,
pubmed-meshheading:3396334-Tritium
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pubmed:year |
1988
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pubmed:articleTitle |
The metabolism and excretion of oestradiol-3 beta-D-glucuronide in rats.
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pubmed:affiliation |
Department of Physiology and Pharmacology, University of Queensland, Australia.
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pubmed:publicationType |
Journal Article
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