Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-9-7
pubmed:abstractText
1. Tritium labelled oestradiol-3 beta-D-glucuronide (E2-3G) was synthesised by sodium borohydride reduction of labelled oestrone-glucuronide (E1-G) and injected intravenously into anaesthetised rats. Bile and urine were collected to assess the routes and rate of excretion of E2-3G. Bile and urine samples were analysed by reverse phase HPLC to determine the metabolites of E2-3G. 2. When E2-3G was given at 11 and 22 mumol/kg, 83 and 85% respectively was excreted in bile within 3 hr and 1 and 3% in urine. 3. The major metabolite was E1-G which accounted for 89 and 92% respectively of the injected E2-3G which was recovered in bile. 4. It is concluded that bile is the major route of excretion of E2-3G in rats and that it is converted mainly to E1-G before excretion.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0305-0491
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
99-101
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
The metabolism and excretion of oestradiol-3 beta-D-glucuronide in rats.
pubmed:affiliation
Department of Physiology and Pharmacology, University of Queensland, Australia.
pubmed:publicationType
Journal Article