| pubmed-article:3396261 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3396261 | lifeskim:mentions | umls-concept:C0006644 | lld:lifeskim |
| pubmed-article:3396261 | lifeskim:mentions | umls-concept:C0231330 | lld:lifeskim |
| pubmed-article:3396261 | lifeskim:mentions | umls-concept:C1291081 | lld:lifeskim |
| pubmed-article:3396261 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:3396261 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3396261 | pubmed:dateCreated | 1988-9-8 | lld:pubmed |
| pubmed-article:3396261 | pubmed:abstractText | The maturation of the different pathways of caffeine metabolism was studied during infancy. The group of children (n = 14) consisted of four premature newborn infants and 10 older infants who received caffeine citrate solution. Caffeine and 11 of its metabolites were measured by HPLC. Total demethylation and N3- and N7-demethylation increase exponentially with postnatal age; the plateau is reached by 120 days and accounts for 58.6%, 90.5%, and 79.3%, respectively. N1-demethylation shows no variation with postnatal age. It is suggested that N3-demethylation is more important in young infants than in adults and that maturation of N1-demethylation occurs later than 19 months of age. 8-Hydroxylation is mature as early as 1 month of age and may be higher in infants than in adults. Acetylation is not mature before at least 1 year of age. Differences in maturation rate of acetylation may be related in part to genetic acetylator status. | lld:pubmed |
| pubmed-article:3396261 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3396261 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396261 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3396261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396261 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3396261 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3396261 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:3396261 | pubmed:issn | 0009-9236 | lld:pubmed |
| pubmed-article:3396261 | pubmed:author | pubmed-author:SHOYY | lld:pubmed |
| pubmed-article:3396261 | pubmed:author | pubmed-author:OliveGG | lld:pubmed |
| pubmed-article:3396261 | pubmed:author | pubmed-author:BadoualJJ | lld:pubmed |
| pubmed-article:3396261 | pubmed:author | pubmed-author:MoradMM | lld:pubmed |
| pubmed-article:3396261 | pubmed:author | pubmed-author:PonsGG | lld:pubmed |
| pubmed-article:3396261 | pubmed:author | pubmed-author:CarrierOO | lld:pubmed |
| pubmed-article:3396261 | pubmed:author | pubmed-author:RichardM OMO | lld:pubmed |
| pubmed-article:3396261 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3396261 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:3396261 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3396261 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3396261 | pubmed:pagination | 145-51 | lld:pubmed |
| pubmed-article:3396261 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:3396261 | pubmed:meshHeading | pubmed-meshheading:3396261-... | lld:pubmed |
| pubmed-article:3396261 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3396261 | pubmed:articleTitle | Maturation of caffeine metabolic pathways in infancy. | lld:pubmed |
| pubmed-article:3396261 | pubmed:affiliation | Department of Clinical Pharmacology, Hôpital Saint-Vincent de Paul, Paris, France. | lld:pubmed |
| pubmed-article:3396261 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3396261 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3396261 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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