|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1988-9-8
|
|
pubmed:abstractText |
The maturation of the different pathways of caffeine metabolism was studied during infancy. The group of children (n = 14) consisted of four premature newborn infants and 10 older infants who received caffeine citrate solution. Caffeine and 11 of its metabolites were measured by HPLC. Total demethylation and N3- and N7-demethylation increase exponentially with postnatal age; the plateau is reached by 120 days and accounts for 58.6%, 90.5%, and 79.3%, respectively. N1-demethylation shows no variation with postnatal age. It is suggested that N3-demethylation is more important in young infants than in adults and that maturation of N1-demethylation occurs later than 19 months of age. 8-Hydroxylation is mature as early as 1 month of age and may be higher in infants than in adults. Acetylation is not mature before at least 1 year of age. Differences in maturation rate of acetylation may be related in part to genetic acetylator status.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0009-9236
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
44
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
145-51
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:3396261-Acetylation,
pubmed-meshheading:3396261-Administration, Oral,
pubmed-meshheading:3396261-Adult,
pubmed-meshheading:3396261-Age Factors,
pubmed-meshheading:3396261-Apnea,
pubmed-meshheading:3396261-Caffeine,
pubmed-meshheading:3396261-Chromatography, High Pressure Liquid,
pubmed-meshheading:3396261-Citrates,
pubmed-meshheading:3396261-Drug Combinations,
pubmed-meshheading:3396261-Female,
pubmed-meshheading:3396261-Humans,
pubmed-meshheading:3396261-Hydroxylation,
pubmed-meshheading:3396261-Infant,
pubmed-meshheading:3396261-Infant, Newborn,
pubmed-meshheading:3396261-Infant, Premature,
pubmed-meshheading:3396261-Male,
pubmed-meshheading:3396261-Pierre Robin Syndrome,
pubmed-meshheading:3396261-Time Factors,
pubmed-meshheading:3396261-Uracil,
pubmed-meshheading:3396261-Xanthines
|
|
pubmed:year |
1988
|
|
pubmed:articleTitle |
Maturation of caffeine metabolic pathways in infancy.
|
|
pubmed:affiliation |
Department of Clinical Pharmacology, Hôpital Saint-Vincent de Paul, Paris, France.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
