Linked Life Data

3395998

Source:http://linkedlifedata.com/resource/pubmed/id/3395998

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
1988-9-8
pubmed:abstractText
The early changes in the metabolism of L-ethionine were examined in rats preexposed to chronic administration of DL-ethionine. The capacity of liver to accumulate S-adenosylethionine after a single injection of L-ethionine decreases rapidly from the onset of the carcinogenic regimen. This drop is caused by diminished S-adenosylethionine synthesis, a consequence of lower activity of the ATP-L-methionine adenosyltransferase. This change is accompanied by the rapid increase of the concentration of free ethionine and ethionine sulfoxide. The concentration of hepatic ATP depends in the control animals on the L-ethionine dose and is inversely related to the S-adenosylethionine concentration, but in DL-ethionine-pretreated rats it becomes gradually independent of the L-ethionine dose. The alterations in L-ethionine metabolism observed are not attributed to the change in the ratio of hepatocytes to oval cells but rather to the functional alterations of hepatocytes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4464-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Formation of S-adenosylethionine in liver of rats chronically fed with DL-ethionine.
pubmed:affiliation
Papanicolaou Comprehensive Cancer Center, University of Miami School of Medicine, Florida 33101.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't