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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1988-8-31
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pubmed:abstractText |
The development of the blood-cerebrospinal fluid (CSF) and cerebrospinal fluid-blood barriers, and the differentiation of the choroidal vessel wall, have been ultrastructurally investigated in the choroidal plexuses of the lateral ventricles of 10, 15, 18 and 21 day chicken embryos, fixed in normal conditions and also after intracardial and intraventricular injection of horseradish peroxidase. In all the analyzed developmental stages the choroidal epithelial cells seem able to endocytose and degradate, in their lysosomal apparatus, the tracer molecules reaching their ventricular and basolateral sides. The intravascularly injected horseradish peroxidase can enter the ventricular cavity by interepithelial route only at 10th incubation day, when the tight intercellular junctions are not formed everywhere, while a transepithelial transport is always hindered. The marker injected into the ventricular cavity reaches the subepithelial compartment and the blood stream, at 10th incubation day by interepithelial as well as transepithelial route and, successively, by transepithelial vesicular transport alone. The differentiation processes undergone by the choroidal blood vessels consist in a progressive thinning of the endothelial cells, appearance of pores, already numerous at 15th incubation day, and formation of the endothelial basement lamina, the final event in vessel wall maturation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1122-9497
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
385-95
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3395977-Animals,
pubmed-meshheading:3395977-Blood-Brain Barrier,
pubmed-meshheading:3395977-Capillaries,
pubmed-meshheading:3395977-Cell Differentiation,
pubmed-meshheading:3395977-Chick Embryo,
pubmed-meshheading:3395977-Choroid Plexus,
pubmed-meshheading:3395977-Horseradish Peroxidase,
pubmed-meshheading:3395977-Injections, Intraventricular,
pubmed-meshheading:3395977-Peroxidases
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pubmed:year |
1988
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pubmed:articleTitle |
The barrier systems in the choroidal plexuses of the chick embryo studied by means of horseradish peroxidase.
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pubmed:affiliation |
Institute of Human Anatomy and Histology and General Embryology, University of Bari, Italy.
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pubmed:publicationType |
Journal Article
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