Linked Life Data

3390701

Source:http://linkedlifedata.com/resource/pubmed/id/3390701

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-8-12
pubmed:abstractText
The major objective of the experiments reported in this paper was to test the hypothesis that the maximum distance that peripheral nervous system (PNS) axons can regenerate through a tubular prosthesis may be increased by specific modifications to the internal environment of the prosthesis. The sciatic nerve of adult male rats was transected and proximal and distal nerve stumps were sutured into a silicone tube 20-25 mm in length. The silicone tubes were implanted empty, or the lumen was filled with collagen or a laminin-containing gel. Following 4-16 weeks survival time animals were sacrificed and the contents of the silicone tubes were processed for histological identification of myelinated and unmyelinated axons. All of the tubes with additives, but one of the initially empty tubes, displayed a regenerated nerve cable within the tube. Retrograde labeling studies were carried out to prove that some of the axons present in the regenerated nerve cables arose from primary motor and sensory neurons. These results show that specific modifications to the microenvironment of regenerating PNS axons can affect the success or failure of tubular prostheses for nerve repair.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
447
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
325-34
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Entubulation repair with protein additives increases the maximum nerve gap distance successfully bridged with tubular prostheses.
pubmed:affiliation
Department of Neuroscience, Children's Hospital, Boston, MA 02115.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.