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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1988-8-18
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pubmed:abstractText |
1. Muscarinic depression of the electrically-evoked surface-negative field potential (N-wave) was measured in guinea-pig olfactory cortex slices maintained in vitro. 2. The effects of three muscarinic receptor antagonists, pirenzepine, atropine and gallamine on this muscarinic response were analysed in detail. 3. Pirenzepine was a potent competitive antagonist of carbachol (CCh)-evoked responses. Schild plot analysis yielded a pA2 value of 7.9 (Schild slope constrained to unity). A similar analysis for atropine versus CCh responses gave a pA2 of 8.9. 4. Combination experiments using pirenzepine and atropine produced dose-ratio shifts close to those expected for two antagonists competing for a similar receptor site. 5. Gallamine was only a weak antagonist of responses to CCh. 6. Oxotremorine behaved as a competitive antagonist at this muscarinic receptor (pA2 = 6.1). 7. It is concluded that the presynaptic muscarinic receptor mediating depression of the N-wave in the olfactory cortex slice is of the M1-subtype.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-13383117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-2418362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-2443678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-2581148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-2862610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-2864975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-3390653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-3762692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-3774154,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-3814922,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-3839571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-3840044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-3942874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-4078746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-6135142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-6141277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-6258681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-6688111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-6707935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-6897666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-7233212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-7350532,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-7470751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390654-990587
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
855-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3390654-Animals,
pubmed-meshheading:3390654-Atropine,
pubmed-meshheading:3390654-Carbachol,
pubmed-meshheading:3390654-Cerebral Cortex,
pubmed-meshheading:3390654-Drug Interactions,
pubmed-meshheading:3390654-Evoked Potentials,
pubmed-meshheading:3390654-Gallamine Triethiodide,
pubmed-meshheading:3390654-Guinea Pigs,
pubmed-meshheading:3390654-Oxotremorine,
pubmed-meshheading:3390654-Parasympathomimetics,
pubmed-meshheading:3390654-Pirenzepine
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pubmed:year |
1988
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pubmed:articleTitle |
A quantitative study of the effects of some muscarinic antagonists on the guinea-pig olfactory cortex slice.
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pubmed:affiliation |
M.R.C. Neuropharmacology Research Group, Dept. of Pharmacology, School of Pharmacy, London.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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