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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1988-8-18
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pubmed:abstractText |
1. Antiarrhythmic actions of ajmaline against ischaemia (left coronary artery occlusion for 15 min) and subsequent reperfusion-induced arrhythmias were investigated in anaesthetized rats. 2. Ajmaline (2 mg kg-1, i.v.) was effective in suppressing ischaemia-induced arrhythmias whether given pre- or post-occlusion. 3. Ajmaline diminished the reperfusion-induced arrhythmias completely when given pre-occlusion but had little effect when given post-occlusion. 4. Reperfusion-induced increases in plasma enzyme activities of lactate dehydrogenase, glutamate-oxaloacetate transaminase and creatine phosphokinase were prevented more effectively when ajmaline was given pre-occlusion rather than post-occlusion. 5. Fifteen min post-occlusion, the ajmaline concentrations in the ischaemic ventricle were 18.42 +/- 1.66 and 1.18 +/- 0.15 micrograms g-1 for pre- and post-occlusion administration, respectively. However, ajmaline concentrations in whole blood and normal ventricle were not significantly different between pre- and post-occlusion administration. 6. We suggest that the beneficial effect of ajmaline against reperfusion-induced arrhythmias is related to the ischaemic myocardial concentration of ajmaline which is markedly affected by the time of drug administration (i.e. pre- and post-occlusion).
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-2434754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-3708225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-3970366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-6084147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-6144760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-6379687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-6487902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-6733362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-7117374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-7260980,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-7379245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-882146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3390652-941834
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-1188
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
93
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
827-32
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3390652-Ajmaline,
pubmed-meshheading:3390652-Animals,
pubmed-meshheading:3390652-Anti-Arrhythmia Agents,
pubmed-meshheading:3390652-Arrhythmias, Cardiac,
pubmed-meshheading:3390652-Aspartate Aminotransferases,
pubmed-meshheading:3390652-Coronary Circulation,
pubmed-meshheading:3390652-Coronary Disease,
pubmed-meshheading:3390652-Creatine Kinase,
pubmed-meshheading:3390652-Electrocardiography,
pubmed-meshheading:3390652-L-Lactate Dehydrogenase,
pubmed-meshheading:3390652-Male,
pubmed-meshheading:3390652-Myocardium,
pubmed-meshheading:3390652-Rats,
pubmed-meshheading:3390652-Rats, Inbred Strains
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pubmed:year |
1988
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pubmed:articleTitle |
Regional myocardial ajmaline concentration and antiarrhythmic activity for ischaemia- and reperfusion-induced arrhythmias in rats.
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pubmed:affiliation |
Department of Pharmacy, Kyoto University Hospital, Faculty of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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