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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1988-8-11
|
| pubmed:abstractText |
Pretreatment with deferrioxamine (DFO, 125-500 mg/kg i.p.) protected male mice against CCl4- or CBrCl3-induced hepatotoxicity which is closely related to an inhibition of iron-dependent lipid peroxidation monitored by ethane exhalation. For allyl alcohol, 1,1-dichloroethylene, dimethylnitrosamine, thioacetamide, bromobenzene and paracetamol no hepatoprotection was achieved with DFO indicating that lipid peroxidation is not involved as a primary mechanism of toxicity. In the case of bromobenzene a marked in vivo lipid peroxidation was observed, which was unaffected by DFO and appears therefore to be iron-dependent.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0031-6989
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
337-43
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:3387462-Animals,
pubmed-meshheading:3387462-Antidotes,
pubmed-meshheading:3387462-Deferoxamine,
pubmed-meshheading:3387462-Drug-Induced Liver Injury,
pubmed-meshheading:3387462-Lipid Peroxides,
pubmed-meshheading:3387462-Liver,
pubmed-meshheading:3387462-Male,
pubmed-meshheading:3387462-Mice,
pubmed-meshheading:3387462-Mice, Inbred Strains,
pubmed-meshheading:3387462-Oxidation-Reduction
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Antidotal effects of deferrioxamine in experimental liver injury--role of lipid peroxidation.
|
| pubmed:affiliation |
Institute of Toxicology, Medical University of Lübeck, Federal Republic of Germany.
|
| pubmed:publicationType |
Journal Article
|