Linked Life Data

3387424

Source:http://linkedlifedata.com/resource/pubmed/id/3387424

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-8-8
pubmed:abstractText
We previously have shown that the response of pancreatic lipase and amylase to changes in diet composition is altered in senescent rats. The present study was designed to determine if the trophic response to a defined gastrointestinal peptide stimulus differed in 3-month (young) and 27-month (aging) Fischer rats. Caerulein-secretin, administered every 8 h for 7 days, induced pancreatic hypertrophy and hyperplasia as judged by increases in pancreatic weight, protein, and DNA content in both groups. A significant increase also occurred in the content of trypsinogen, amylase, lipase and the polyamines, putrescine, spermine, and spermidine. To quantify differences in the trophic response between young and aging rats, the ratios of data in the treated animals relative to that observed in controls were determined. Pancreatic weight, protein content, and protein DNA ratio increased significantly more in young than in aging treated animals. DNA also increased more but did not reach significance. Pancreatic trypsinogen and lipase content increased significantly more in younger animals, whereas amylase responses were not different between the two groups. Stimulation of pancreatic putrescine and spermidine was also greater in young than in aged animals. We conclude that trophic responses of the pancreas are altered in senescent rats.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0885-3177
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
311-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Trophic responses of the pancreas differ in aging rats.
pubmed:affiliation
Division of Gastroenterology, St. Luke's/Roosevelt Hospital Center, New York, New York.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't