Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1988-8-3
|
| pubmed:abstractText |
Addition of carbamazepine to phenytoin monotherapy resulted in the following significant (p less than 0.05) changes: (1) increased mean phenytoin serum concentration; (2) decreased phenytoin clearance, due to decreased production of phenytoin dihydrodiol and p-hydroxyphenyl-phenylhydantoin; (3) increased phenytoin elimination half-life; and (4) increased drug-related toxicity. Close monitoring is required after addition of carbamazepine to phenytoin.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0028-3878
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
38
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1146-50
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3386835-Adult,
pubmed-meshheading:3386835-Carbamazepine,
pubmed-meshheading:3386835-Drug Therapy, Combination,
pubmed-meshheading:3386835-Epilepsy,
pubmed-meshheading:3386835-Humans,
pubmed-meshheading:3386835-Male,
pubmed-meshheading:3386835-Middle Aged,
pubmed-meshheading:3386835-Phenytoin,
pubmed-meshheading:3386835-Time Factors
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Carbamazepine increases phenytoin serum concentration and reduces phenytoin clearance.
|
| pubmed:affiliation |
Department of Neurology, Boston University School of Medicine, MA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|