Linked Life Data

3386747

Source:http://linkedlifedata.com/resource/pubmed/id/3386747

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6177
pubmed:dateCreated
1988-8-8
pubmed:abstractText
Recent growth studies in children suggest that there is no threshold for adverse effects from the universal exposure to inorganic lead. The biochemical mechanisms mediating low-level toxicity are unclear, but in several biological systems, lead alters calcium-mediated cellular processes and may mimic calcium in binding to regulatory proteins. Here we present evidence that lead stimulates diacylglycerol-activated calcium and phospholipid-dependent protein kinase, protein kinase C, partially purified from rat brain. Picomolar concentrations of lead are equivalent to micromolar calcium in kinase activation, so this regulatory enzyme is sensitive to the lead levels expected from current environmental exposure.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0028-0836
pubmed:author
pubmed:issnType
Print
pubmed:day
7
pubmed:volume
334
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
71-3
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Picomolar concentrations of lead stimulate brain protein kinase C.
pubmed:affiliation
Department of Pediatrics, University of Michigan Medical School, Ann Arbor 48109-0570.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.