Linked Life Data

3386646

Source:http://linkedlifedata.com/resource/pubmed/id/3386646

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-8-3
pubmed:abstractText
IgG2 subclass deficiency associated with poor antibody response to polysaccharide antigen is a now well-described entity. A newer entity which appears to be at least as common is the recurrent infection with a selective deficiency in the antibody response. At the present time, the antibody response to Haemophilus influenzae type b (Hib) is a good marker for the selective antibody deficiency in these children, as the vast majority of such children made a very poor antibody response to Hib. The data suggest that treatment of these children with prophylactic antibiotics and/or with IV gamma-globulin, depending on the clinical situation, is beneficial. This reinforces the view that the observed abnormality in the antibody response may be causally related to the recurrent infections. Prospective studies of the 10% of 'normal' children who fail to respond to soluble polysaccharide antigen would reveal if there is within this group a higher incidence of recurrent infections. The result of such studies will be important in our understanding of normal as well as abnormal selective antigen-specific antibody deficiencies in children.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0077-0760
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
97-102
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
IgG antibody response to polysaccharides in children with recurrent infections.
pubmed:affiliation
Children's Hospital, Boston, Mass.
pubmed:publicationType
Journal Article