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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1988-8-1
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pubmed:abstractText |
Hepatoma cells derived from the Reuber H35 rat hepatoma express cytochrome P450 enzymes of two major families: polycyclic aromatic hydrocarbon-inducible forms are found in both differentiated and dedifferentiated cells while phenobarbital (PB)-inducible forms are found only in differentiated cells. We report here that (i) benzanthracene and PB induce P450 c mRNA in differentiated and dedifferentiated cells and (ii) dexamethasone and PB induce P450 b/e and/or P450 PB1 mRNAs in differentiated cells but not in dedifferentiated cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
233
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
37-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3384091-Animals,
pubmed-meshheading:3384091-Benz(a)Anthracenes,
pubmed-meshheading:3384091-Cell Differentiation,
pubmed-meshheading:3384091-Cytochrome P-450 Enzyme System,
pubmed-meshheading:3384091-Dexamethasone,
pubmed-meshheading:3384091-Gene Expression Regulation,
pubmed-meshheading:3384091-Liver Neoplasms, Experimental,
pubmed-meshheading:3384091-Male,
pubmed-meshheading:3384091-Nucleic Acid Hybridization,
pubmed-meshheading:3384091-Phenobarbital,
pubmed-meshheading:3384091-RNA, Messenger,
pubmed-meshheading:3384091-Rats,
pubmed-meshheading:3384091-Rats, Inbred ACI
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pubmed:year |
1988
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pubmed:articleTitle |
Phenobarbital, dexamethasone and benzanthracene induce several cytochrome P450 mRNAs in rat hepatoma cells.
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pubmed:affiliation |
Département de Biologie Moléculaire, Institut Pasteur, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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