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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1988-8-4
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pubmed:abstractText |
The peptide leukotrienes are biologically active eicosanoids which have recently been implicated as possible mediators of anaphylactic, endotoxic, traumatic, and splanchnic artery occlusion shock. We studied the effects of a novel selective peptide leukotriene antagonist, L-649,923, in a rat model of hemorrhagic shock. Hemorrhaged rats treated with L-649,923 (1 mg/kg/h) maintained post-reinfusion mean arterial blood pressure (MABP) at significantly higher values than rats receiving either 0.9% NaCl or a lower dose (0.2 mg/kg/h) of L-649,923 (final MABP 97 +/- 4 vs 60 +/- 5, p less than 0.01; vs 60 +/- 4 mm Hg, p less than 0.01, respectively). Both doses of L-649,923 attenuated the increase in plasma cathepsin D activity (p less than 0.01). L-649,923, at 1 mg/kg/h, also attenuated the plasma accumulation of free amino-nitrogen compounds (p less than 0.05). Furthermore, the plasma activity of a myocardial depressant factor (MDF) was significantly lower in rats treated with L-649,923 (1 mg/kg/h) than in rats receiving the lower dose of the drug or the vehicle (36 +/- 5 U/ml vs. 61 +/- 4 U/ml, p less than 0.01; and 60 +/- 3 U/ml, p less than 0.01, respectively). Furthermore, L-649,923 does not inhibit platelet aggregation in platelet rich plasma. Our data suggest that peptide leukotrienes are important mediators of hemorrhagic shock and that blockade of leukotriene-induced vasoconstriction may underlie the beneficial effects of L-649,923 in hemorrhagic shock.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin D,
http://linkedlifedata.com/resource/pubmed/chemical/L 649923,
http://linkedlifedata.com/resource/pubmed/chemical/Myocardial Depressant Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylbutyrates,
http://linkedlifedata.com/resource/pubmed/chemical/SRS-A
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0092-6213
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
159-68
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:3383353-Animals,
pubmed-meshheading:3383353-Blood Pressure,
pubmed-meshheading:3383353-Cathepsin D,
pubmed-meshheading:3383353-Male,
pubmed-meshheading:3383353-Myocardial Depressant Factor,
pubmed-meshheading:3383353-Phenylbutyrates,
pubmed-meshheading:3383353-Platelet Aggregation,
pubmed-meshheading:3383353-Rats,
pubmed-meshheading:3383353-Rats, Inbred Strains,
pubmed-meshheading:3383353-SRS-A,
pubmed-meshheading:3383353-Shock, Hemorrhagic
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pubmed:year |
1988
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pubmed:articleTitle |
Beneficial actions of antagonism of peptide leukotrienes in hemorrhagic shock.
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pubmed:affiliation |
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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