Linked Life Data

3381010

Source:http://linkedlifedata.com/resource/pubmed/id/3381010

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-7-19
pubmed:abstractText
Altered calcium homeostasis may play a central role in the liver injury produced by some toxicants. Therefore, the dose and time dependent effects of TCDD on calcium distribution in whole homogenate and subcellular fractions of liver were examined. Groups of female rats were treated with 40 micrograms TCDD/kg for 1, 2 or 3 days. Animals treated with TCDD for 1 and 2 days were killed 1 day after treatment. Rats treated for 3 days were killed on days 1, 3, 5, 7, 9 and 12 post-treatment. A 2-fold increase in calcium content in whole homogenate occurred 5 days post-treatment. Increases in mitochondrial calcium were noted 3 days post-treatment, and significant increases in microsomal calcium were observed one day post-treatment. Small increases in cytosolic calcium also occurred. Thus, TCDD produces disturbances in the content and subcellular distribution of calcium which may contribute to the promotion of toxic manifestations by this xenobiotic.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0034-5164
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-56
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induced perturbation of calcium distribution in the rat.
pubmed:affiliation
Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha 68105.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't