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rdf:type |
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lifeskim:mentions |
umls-concept:C0016129,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0029016,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0332256,
umls-concept:C0543431,
umls-concept:C0851285,
umls-concept:C2700640,
umls-concept:C2825407,
umls-concept:C2911684
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pubmed:issue |
4
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pubmed:dateCreated |
1988-7-25
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pubmed:abstractText |
We isolated and sequenced a cDNA clone of the human gene encoded by the 5' half of the ret transforming gene. The nucleotide sequence indicates that it encodes a protein with "finger" structures which represent putative metal- and nucleic acid-binding domains. Transcription of this gene was detected at high levels in a variety of human and rodent tumor cell lines, mouse testis, and embryos. In addition, a unique transcript was observed in testis RNA. When the expression of the unique transcript was examined at different stages of spermatogenesis, a striking increase in mRNA levels accompanied progression from meiotic prophase pachytene spermatocytes to postmeiotic round spermatids. This finger-containing gene may thus function in male germ cell development.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-2421409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-2423252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-2869410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-2955407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-2992805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-3000623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-3037315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-3515197,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-3550433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-3561413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-3594566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-3785223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-3815523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-3935797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-4022010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-4022013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-4040853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-6086146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-6088992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-6264461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-6468765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-6701535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3380101-885030
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0270-7306
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1853-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3380101-Amino Acid Sequence,
pubmed-meshheading:3380101-Base Sequence,
pubmed-meshheading:3380101-Binding Sites,
pubmed-meshheading:3380101-Cell Line, Transformed,
pubmed-meshheading:3380101-DNA,
pubmed-meshheading:3380101-Gene Expression Regulation,
pubmed-meshheading:3380101-Genes,
pubmed-meshheading:3380101-Humans,
pubmed-meshheading:3380101-Molecular Sequence Data,
pubmed-meshheading:3380101-Proteins,
pubmed-meshheading:3380101-Transcription, Genetic
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pubmed:year |
1988
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pubmed:articleTitle |
Developmentally regulated expression of a human "finger"-containing gene encoded by the 5' half of the ret transforming gene.
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pubmed:affiliation |
Laboratory of Experimental Pathology, Aichi Cancer Center Research Institute, Nagoya, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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