Linked Life Data

3379400

Source:http://linkedlifedata.com/resource/pubmed/id/3379400

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pubmed-article:3379400pubmed:abstractTextThe effects of hypoxia and hypoglycaemia on the redox state in vitro have been studied. NADH and NAD+ were extracted simultaneously from superfused cerebral cortex slices and assayed by bioluminescence. The results show a nonsignificant increase in NADH and the redox ratio in "mild hypoxia," whereas "severe hypoxia" produced an increase of over 200% in NADH and in the NADH/NAD+ ratio. When the glucose in the incubation medium was reduced from its control value of 10 mM to 0.5 mM, significant decreases in NADH and the redox ratio to 60% of control value were observed. Further decreasing the glucose to 0.2 mM gave lower levels of NADH and the redox ratio (40% of control). The effects on the redox state of alternative substrates to glucose were also tested. Replacement of glucose by 10 mM pyruvate decreased the NADH by 77% and the NADH/NAD+ ratio by 79%. Replacement of glucose with 10 mM lactate gave decreases of 70% and 71%, respectively, whereas in the presence of 15 mM 2-deoxyglucose and 5 mM glucose, the NADH was decreased by 56% and the ratio by 50%. The results are discussed in relation to levels of creatine phosphate and ATP, as well as evoked action potentials, observed from parallel studies.lld:pubmed
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pubmed-article:3379400pubmed:articleTitleBrain levels of NADH and NAD+ under hypoxic and hypoglycaemic conditions in vitro.lld:pubmed
pubmed-article:3379400pubmed:affiliationDivision of Biochemistry, U.M.D.S. (St. Thomas's), London, England.lld:pubmed
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pubmed-article:3379400pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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