Linked Life Data

3378571

Source:http://linkedlifedata.com/resource/pubmed/id/3378571

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-7-15
pubmed:abstractText
The possibility that the pressor effects of angiotensin II influence angiotensin-induced thirst was investigated in dogs pretreated with hexamethonium. Ganglionic blockade reduced drinking elicited by i.c.v. administration of angiotensin II and totally eliminated drinking elicited by i.v. infusion of angiotensin II, whereas the pressor response to i.v. and i.c.v. angiotensin II was significantly increased. In contrast, hexamethonium had no effect on water intake or mean arterial blood pressure following i.c.v. isoproterenol, and produced a significant increase in drinking to s.c. isoproterenol, which was preceded by a large fall in mean arterial pressure. No changes in mean arterial pressure or drinking were observed during NaCl infusion in hexamethonium-pretreated animals. These results suggest that angiotensin II exerts its full dipsogenic activity only during normotensive or hypotensive states, and that the pressor effect of angiotensin II can antagonize its effects on water intake.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
148
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
213-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Inhibition of angiotensin-induced water intake following hexamethonium pretreatment in the dog.
pubmed:affiliation
Department of Physiology, Health Sciences Centre, Ottawa, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't