Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1988-6-27
|
| pubmed:abstractText |
Compound U-76,253A (R-3746), the active metabolite sodium salt of the prodrug ester U-76,252 (CS-807), was demonstrated to be active against members of the family Enterobacteriaceae with 82 and 85% of strains inhibited by less than or equal to 2.0 and less than or equal to 4.0 micrograms/ml, respectively. In addition, U-76,253A inhibited all strains of Branhamella catarrhalis, Haemophilus influenzae, pathogenic Neisseria spp., oxacillin-susceptible Staphylococcus aureus, beta-hemolytic streptococci, and pneumococci at less than or equal to 4.0 micrograms/ml. Pseudomonas spp., Acinetobacter spp., enterococci, and oxacillin-resistant staphylococci were resistant to U-76,253A. This U-76,253A antimicrobial activity and spectrum was generally superior to that of comparison orally administered cephems (cefaclor, cefuroxime, and cefixime) and the amoxicillin-clavulanic acid combination. Tests with beta-lactamase-producing isolates indicated that U-76,253A was bactericidal and that its MICs were only influenced by high inoculum concentrations (10(7) CFU/ml) against type Ia and IVc enzyme-producing strains. Preliminary disk diffusion interpretive zone criteria were calculated for 10- and 30-micrograms U-76,253A disks and several possible susceptible MIC breakpoints. The absolute interpretive agreement between MICs and zone diameters ranged from 87.8 to 95.6%. Final selection of interpretive criteria awaits further U-76,252 pharmacokinetic information.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-1259407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-3105449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-3310868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-3499115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-3570989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-3654953,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-3691031,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-3729361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-3771755,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-4372272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-6561017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-6703686,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-6874906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-6903436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3377457-7447427
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0066-4804
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
443-9
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading | |
| pubmed:year |
1988
|
| pubmed:articleTitle |
Antimicrobial activity and disk diffusion susceptibility testing of U-76,253A (R-3746), the active metabolite of the new cephalosporin ester, U-76,252 (CS-807).
|
| pubmed:affiliation |
Clinical Microbiology Institute, Tualatin, Oregon 97062.
|
| pubmed:publicationType |
Journal Article
|