Linked Life Data

3374258

Source:http://linkedlifedata.com/resource/pubmed/id/3374258

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
22
pubmed:dateCreated
1988-7-5
pubmed:abstractText
Analysis of dopamine and 3-MT dynamics in the striatum and in striatal dialysates, after pargyline treatment, indicates that the 3-MT pool in the rat is smaller but more dynamic than that in the mouse. The fractional rate constants calculated for the extracellular 3-MT and dopamine pools also indicate that a larger proportion of released dopamine is metabolized to 3-MT in the rat, or alternatively, 3-MT is cleared more slowly from the mouse striatum. Our striatal dialysis data also support previous in vivo voltammetry studies which have demonstrated that the fractional rate constant of the extracellular dopamine pool is at least 10-fold greater than that of the total striatal dopamine pool. These data suggest that multiple striatal dopamine pools exist and that a minimum of 20 to 30% of the extracellular DA pool is metabolized to 3-MT.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2275-81
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Dynamics of the striatal 3-MT pool in rat and mouse: species differences as assessed by steady-state measurements and intracerebral dialysis.
pubmed:affiliation
Neuroscience Research, CIBA-GEIGY Corp., Summit, N.J. 07901.
pubmed:publicationType
Journal Article, Comparative Study