| pubmed-article:3372018 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3372018 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:3372018 | lifeskim:mentions | umls-concept:C0318342 | lld:lifeskim |
| pubmed-article:3372018 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:3372018 | lifeskim:mentions | umls-concept:C0025252 | lld:lifeskim |
| pubmed-article:3372018 | lifeskim:mentions | umls-concept:C1545588 | lld:lifeskim |
| pubmed-article:3372018 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:3372018 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3372018 | lifeskim:mentions | umls-concept:C1334043 | lld:lifeskim |
| pubmed-article:3372018 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:3372018 | pubmed:dateCreated | 1988-6-30 | lld:pubmed |
| pubmed-article:3372018 | pubmed:abstractText | Immunization of cattle with a purified Anaplasma marginale major surface protein, AmF36, induced protection against homologous challenge with the Florida isolate. Similarly, immunized cattle were protected from challenge with the antigenically and structurally distinct Washington-O isolate of A. marginale. The degree of protection in AmF36-immunized cattle varied from complete prevention of rickettsemia to significant delay in the onset of rickettsemia compared with control immunized cattle. A single AmF36 vaccinate was not protected against homologous challenge despite development of a strong antibody response. Immunoprecipitation of A. marginale proteins with a monoclonal antibody to AmF36 identified minor molecular size heterogeneity in this protein from different isolates, including the Florida and Washington-O isolates. The apparent molecular size of this surface protein in the Florida isolate was 36 kilodaltons, whereas the analogous proteins in Washington-O and four other isolates of A. marginale from the United States had molecular masses of 33 to 34 kilodaltons. Significantly, the surface-exposed peptides of these proteins appear to be conserved among the different isolates. These results demonstrate the potential of AmF36 as a subunit immunogen for bovine anaplasmosis and indicate a structural basis for its cross-protective ability. | lld:pubmed |
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| pubmed-article:3372018 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3372018 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3372018 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3372018 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3372018 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3372018 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:3372018 | pubmed:author | pubmed-author:McGuireT CTC | lld:pubmed |
| pubmed-article:3372018 | pubmed:author | pubmed-author:BarbetA FAF | lld:pubmed |
| pubmed-article:3372018 | pubmed:author | pubmed-author:DavisW CWC | lld:pubmed |
| pubmed-article:3372018 | pubmed:author | pubmed-author:PalmerG HGH | lld:pubmed |
| pubmed-article:3372018 | pubmed:author | pubmed-author:GoffW LWL | lld:pubmed |
| pubmed-article:3372018 | pubmed:author | pubmed-author:OberleS MSM | lld:pubmed |
| pubmed-article:3372018 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3372018 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:3372018 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3372018 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3372018 | pubmed:pagination | 1526-31 | lld:pubmed |
| pubmed-article:3372018 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3372018 | pubmed:meshHeading | pubmed-meshheading:3372018-... | lld:pubmed |
| pubmed-article:3372018 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3372018 | pubmed:articleTitle | Immunization of cattle with a 36-kilodalton surface protein induces protection against homologous and heterologous Anaplasma marginale challenge. | lld:pubmed |
| pubmed-article:3372018 | pubmed:affiliation | Department of Comparative and Experimental Pathology, University of Florida, Gainesville 32610. | lld:pubmed |
| pubmed-article:3372018 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3372018 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:3372018 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:3372018 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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